delta beta|Delta : Tagatay Delta-beta thalassemia trait refers to a genetic condition in which a person has inherited one abnormal gene for the beta-globin subunit of hemoglobin, the oxygen-carrying protein found in red blood cells from one parent and one normal gene from the other parent.
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Delta-beta thalassemia is a rare form of thalassemia in which there is a reduced production of hemoglobin subunit delta and hemoglobin subunit beta and raised levels of hemoglobin subunit gamma. It is an autosomal recessive disorder .δβ-Thalassemia results from the deletion of both δ and βgenes. Homozygotes for δβ-thalassemia have 100% HbF and, because of the increased synthesis of HbF, may have thalassemia intermedia rather than thalassemia major [1].
DeltaDelta-beta-thalassemia is a form of beta-thalassemia characterized by decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis.
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Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature.
Delta-beta thalassemia trait refers to a genetic condition in which a person has inherited one abnormal gene for the beta-globin subunit of hemoglobin, the oxygen-carrying protein found in red blood cells from one parent and one normal gene from the other parent.
Beta-thalassemia (β-thalassemia) has two clinically significant forms, β-thalassemia major and β-thalassemia intermedia, caused by absent or reduced synthesis of the hemoglobin subunit beta (beta globin chain).delta beta Delta-beta (δβ) thalassemia trait is an autosomal recessive hereditary hemoglobinopathy resulting from point mutations in both the delta and beta-globin genes. This condition is found in both homozygous and heterozygous forms with varied clinical presentations and haematological findings.
delta beta|Delta
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PH3 · Delta beta thalassemia: a rare hemoglobin variant
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